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. 2018 Jun 19;9:753. doi: 10.3389/fphys.2018.00753

FIGURE 2.

FIGURE 2

The gap junction blocker 18β-glycyrrhetic acid inhibits ZD7288-enhanced contractility. (A) Sample force recording showing that pre-treatment with 100 μM 18β-glycyrrhetic acid (18β-GA) inhibited alter ZD7288-induced contractility changes. (B) Pre-established ZD7288-enhanced contractility was sensitive to 18β-GA application. (C) Tonic contractions induced by ZD7288 were significantly reduced by 18β-GA pre-treatment (P < 0.001, paired t-test). (D) Phasic contraction amplitudes were significantly enhanced by ZD7288 (P < 0.01, Wilcoxon signed rank test). However, in the presence of 18β-GA, the ZD7288-induced increase was prevented. Note that the ZD7288-induced increase was significantly lower in 18β-GA incubation (P < 0.01, Mann–Whitney U-test). (E) Pre-established enhancement of phasic contractions following ZD7288 were significantly reduced by 18β-GA (P < 0.001, paired t-test).