| Baruch et al.20 1984 |
Israel |
7 female PBC patient compared with 6 age-matched controls |
Increased HDL and decreased platelet aggregation in PBC patients |
| Crippin et al.17 1992 |
USA |
312 patients with PBC compared to age- and sex-matched controls |
Increased HDL in PBC patients |
| Gregory et al.27 1994 |
UK |
42 patients with PBC compared to 39 age- and sex-matched subjects with non-PBC liver disease and 432 community control subjects |
Decreased lipoprotein(a) concentrations in the PBC group compared with the healthy controls (28.5 mg/L vs. 75.0 mg/L, p < 0.005) |
| Romics et al.26 1996 |
Hungary |
39 female PBC patients compared to 39 female controls |
Despite the elevation of overall lipoproteins in PBC patients, there was no difference in lipoprotein(a) levels between the two groups (10 mg/dL vs. 11.5 mg/dL, p = 0.64) |
| O’Kane et al.24 1997 |
UK |
31 patients with PBC compared to 27 control subjects |
PBC is associated with an altered distribution of apolipoprotein A1 favoring an increased concentration of the protective LpA-I particle |
| Chang et al.32 2004 |
Taiwan |
6 PBC patients compared to healthy controls |
Patients with hypercholesterolemia and PBC have a substantial portion of circulating lipoprotein X |
| Su et al.33 2007 |
Taiwan |
13 PBC patients compared to age-matched 71 patients with hypercholesterolemia |
Prolonged LDL oxidation lag time in patients with PBC |
| Floreani et al.31 2008 |
Italy |
137 PBC patients compared with 30 patients with NASH/metabolic syndrome and 137 matched controls found that |
Significantly higher adiponectin, resistin and leptin concentrations in PBC patients than both NASH patients and controls (p < 0.05) |
