| Simvastatin |
| Del Puppo et al.45 2001 |
Italy |
Single-center, prospective study |
30 days |
6 patients with PBC treated with simvastatin (40 mg daily) |
Significant reduction in total cholesterol (34% in 30 days) |
| Cash et al.46 2013 |
UK |
Single-blind, randomized control study |
1 year |
21 patients with PBC received simvastatin (20 mg daily) or matched placebo |
Significantly lower cholesterol in treatment arm (p = 0.01) but no significant difference in pulse wave velocity (p = 0.66) |
| Atorvastatin |
| Stanca et al.47 2008 |
USA |
Retrospective study |
Median 2.5 years |
15 patients with PBC treated with atorvastatin compared to age- and sex-matched PBC patients who did not receive statin treatment |
Significant reduction in cholesterol (p < 0.002) |
| Stojakovic et al.48 2007 |
Austria |
Single-center, prospective study |
20 weeks |
15 patients with PBC treated with atorvastatin (at 10 mg/day, 20 mg/day and 40 mg/day) for 4 weeks respectively |
Significant reduction in total cholesterol (35%, p < 0.001) |
| Stojakovic et al.49 2009 |
Austria |
Single-center, prospective study |
1 year |
19 patients with PBC treated with atorvastatin (10 mg daily) |
Significant reduction in total cholesterol and improvement in vascular function. No effect on cholestasis progression. |
