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Streptococcus ComABCDE QS pathway. ComC is processed intracellularly and secreted by ComAB as the mature CSP. Upon reaching a threshold concentration, CSP binds and activates its cognate receptor, ComD. Activation of ComD leads to ComE phosphorylation, which results in the autoinduction of the QS circuitry (ComABCDE) and the expression of comX, the master regulator of QS-dependent phenotypes.
