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. 2018 Jun 19;9:451. doi: 10.3389/fneur.2018.00451

Figure 2.

Figure 2

EPO treatment resolves deficits in cognitive flexibility. (A) Fewer vehicle-treated CCI rats passed reversal compared to shams or EPO-treated rats. (B) Vehicle-treated CCI rats required at least 50% more correction trials than shams or EPO-treated CCI rats (two-way ANOVA with Bonferroni's correction). (C) Vehicle-treated CCI rats also required more sessions to achieve passing criteria. (D) Similarly, vehicle-treated CCI rats committed more errors prior to reaching passing criteria. (E) Importantly, vehicle-treated CCI rats showed significant perseveration and required more correction trials during the perseverative phase than shams or EPO-treated CCI rats. (F) By contrast, rats from all 3 groups showed no difference during the learning phase. (G) Similar to VD, rats in all 3 groups demonstrated similar reaction times. (H) Rats in all three groups exhibited similar motivation to retrieve a reward for a correct response (n = 6–8, *p < 0.05).