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. 2018 Jun 19;5:57. doi: 10.3389/fmolb.2018.00057

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Copyright © 2018 Housseini B Issa, Phan and Broutin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation systems of the RND efflux pumps involved in antibiotic resistance from P. aeruginosa. Genes are schemed as arrows, proteins are oval shaped. The MFP are in yellow, the RND in green, the OMF in blue. The regulators from the TetR family are in orange, the MexR regulator from the MarR family is in salmon, MexT from the LysR family is in purple, CmrA coded by an AraC regulator is in light purple written in red, TCS are in gray written in red, all the other partners are in gray, written in black. Repression is indicated by “–“ sign and activation is indicated by “+” sign. All the 3D structures are generated with PyMol (http://www.pymol.org; DeLano, 2009).