Table 3.
Logical rules for the nodes of the p53-Mdm2 model.
| Regulatory nodes | Target levels | Boolean rules |
|---|---|---|
| p53 | 2 | !Mdm2nuc |
| Mdm2cyt | 2 | p53 |
| 1 | !p53 | |
| Mdm2nuc | 1 | Mdm2cyt:2 | (Mdm2cyt:1 & !p53 & !DNAdam) |
| DNAdam | 1 | DNAdam & !p53 |
This table lists the conditions enabling the activation of each node (up to level one in the case of a Boolean node, potentially up to higher levels for multi-valued nodes, as for p53 and Mdm2cyt here). These conditions are defined in term of Boolean expressions using the NOT, AND and (inclusive) OR Boolean operators (denoted by !, & and | in GINsim, respectively).