Table 5.
Uni- and multivariate association of response with CDR1-AS, hsa-miR-7 and other clinical variables in the predictive cohort.
| Parameters base model | univariate model | multivariate model | |||||
|---|---|---|---|---|---|---|---|
| n | OR | (95% CI) | P | OR | (95% CI) | P | |
| 188 | |||||||
| Age at start 1 st -line tamoxifen | |||||||
| ≤55 years | 75 | 1 | 1 | ||||
| 56–70 years | 67 | 1.63 | (0.82–3.25) | 0.16 | 1.23 | (0.55–2.72) | 0.61 |
| >70 years | 46 | 3.06 | (1.29–7.23) | 0.011 | 2.05 | (0.81–5.18) | 0.13 |
| Disease-free interval | |||||||
| ≤1 year | 76 | 1 | 1 | ||||
| 1–3 years | 48 | 1.52 | (0.71–3.25) | 0.28 | 1.44 | (0.63–3.30) | 0.38 |
| >3 years | 64 | 2.07 | (0.99–4.28) | 0.05 | 1.88 | (0.86–4.14) | 0.12 |
| Dominant site of relapse | |||||||
| Local regional | 21 | 1 | 1 | ||||
| Bone | 101 | 0.25 | (0.07–0.92) | 0.037 | 0.20 | (0.05–0.77) | 0.020 |
| Other distant metastasis | 66 | 0.41 | (0.11–1.56) | 0.19 | 0.28 | (0.07–1.19) | 0.08 |
| Hormone/Growth factor receptors* | |||||||
| ER (log continuous ESR1) | 188 | 1.65 | (1.22–2.23) | 0.001 | 1.65 | (1.15–2.36) | 0.006 |
| PR (log continuous PGR) | 188 | 1.07 | (0.92–1.25) | 0.39 | 1.00 | (0.84–1.20) | 0.99 |
| HER2 (ERBB2) status | |||||||
| Not amplified | 165 | 1 | 1 | ||||
| Amplified | 23 | 0.60 | (0.25–1.45) | 0.26 | 0.97 | (0.33–2.85) | 0.96 |
| hsa-miR-7 separately added to the base model | |||||||
| CDR1-AS (log continuous) | 188 | 1.01 | (0.78–1.31) | 0.96 | |||
| hsa-miR-7 (log continuous) | 188 | 0.76 | (0.60–0.96) | 0.023 | 0.73 | (0.57–0.95) | 0.017 |
| ≤median | 94 | 1 | 1 | ||||
| >median | 94 | 0.56 | (0.30–1.03) | 0.064 | 0.59 | (0.30–1.16) | 0.13 |
The association of the different parameters, including CDR1-AS and hsa-miR-7 expression, with the therapy response in the predictive cohort is displayed on the left side of the table. The hormone/growth factor receptor expression values used in this table were determined by qPCR. * Cut-offs for positive and negative hormone receptor/growth factor status were established as previously described56,57. The same parameters are assessed with a multivariate model on the right side. n = number of patients, OR = odds ratio, CI = confidence interval, and P = p-value. Significant p-values are highlighted in bold.