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. 2018 Jun 6;24:3804–3814. doi: 10.12659/MSM.907734

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© Med Sci Monit, 2018

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Melatonin treatment upregulated SIRT3 expression by increasing SIRT3 promoter transcription efficiency. (A) Melatonin treatment upregulated SIRT3 expression in cells in the U87 cell line compared with the normal control (NC) group. (B) SIRT3 expression in cells in the U251 cell line was upregulated following treatment with melatonin when compared with NC group. (C) Treatment with melatonin increased luciferase activity driven by the SIRT3 promoter in cells in the U87 cell line. (D) The SIRT3 promoter was upregulated in cells in the U87 cell line following treatment with melatonin.