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. 2018 Jun 25;8:9629. doi: 10.1038/s41598-018-27897-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

GSEA and LEGA declare the most significant pathways and genes related with TIMP-2 based on GSE62254 and GSE15459. GSE62254 and GSE15459 share 4 gene sets (A) and 35 (B) leading-edge genes that are related with TIMP-2 expression. The correlation of TIMP2 levels with the 4 hallmark gene-sets, including “EPITHELIAL_MESENCHYMAL_TRANSITION” (C), “ANGIOGENESIS” (D), “APICAL_JUNCTION” (E) and “UV_RESPONSE_DN” (F), are illustrated, and the overlapped leading-edge genes in GSE62254 are shown (G).