Table 1.
Top 10 miRNAs with previously reported development-associated functions.
| miRNAs | Expression pattern | Reported functions in lineages |
|---|---|---|
| miR-10a-5p | HD 10 (up) | Liver fibrosis62 |
| miR-122-5p | HD 6-10 (up) | Expressed in developing liver tissue63/Liver-specific miRNA and maintenance of adult-liver phenotype35,36/Cholesterol and lipid metabolism36,64 |
| miR-124-3p | HD 3–10 (down) | Cholangiocyte proliferation65/Brain-specific miRNA65,66 |
| miR-146b-5p | HD 10 (up) | Intestinal epithelial cell differentiation67/Visceral preadipocyte proliferation and differentiation68/Regulator of inflammation in epithelial cells, lung fibroblasts and others69 |
| miR-184 | HD 10 (up) | — |
| miR-192-5p/194-3p | HD 6–10 (up) | Liver-abundant miRNAs70/Intestinal epithelial cell differentiation71 |
| miR-489-3p | HD 3 (enriched) | Increased in all germ layers, highest in the endoderm11 |
| miR-517a-3p/-526b-5p | HD 3–10 (down) | Members of C19MC cluster, which is involved in pluripotent stem cell status72,73 |
| miR-10a-5p | KD 6 (enriched) | Biomarkers of kidney injury74 |
| miR-10b-5p | KD 6 (enriched) | — |
| miR-181a-5p | KD 10 (up) | Expressed in kidney tissue75/Hematopoietic lineage differentiation75 |
| miR-214–3p | KD 10 (up) | Differentiation of ESCs into endothelial cells76/Osteogenic differentiation77 |
| miR-302a-5p/3p/-302c-5p/-302d-5p | KD 10 (down) | hPSC-specific miRNAs22/Definitive endoderm formation12 |
| miR-371a-3p | KD 10 (down) | hPSC-specific miRNAs22/Mesendoderm specification78 |
| let-7e-5p | KD 10 (up) | Early nephrogenic differentiation38 |
| miR-10a-5p | ND 10 (up) | Neuron differentiation79 |
| miR-181a-2-3p | ND 3 (down) | Regulation of synaptic functions80 |
| miR-1208 | ND 6 (enriched) | — |
| miR-375 | ND 6–10 (up) | Inhibition of neurite differentiation81/Spinal motor neuron development82 |
| miR-4470 | ND 3–6 (up) | — |
| miR-520a-5p/-520g-3p/-526b-5p | ND 3–10 (down) | Members of C19MC cluster, which is involved in pluripotent stem cell status72,73 |
| miR-664b-5p | ND 3–10 (up) | — |
| miR-934 | ND 6–10 (up) | — |