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Identification of the product of psoralen metabolization by CYP71AZ4. Yeast microsomes expressing CYP71AZ4 convert psoralen to xanthotoxol (P03). (A) HPLC profile of enzyme assays containing psoralen, without (line 1) or with (line 2) NADPH, oxygen, and yeast microsomes expressing CYP71AZ4. (B) MS and absorption spectrum of standard xanthotoxol. (C) MS and absorption spectrum of P03.
