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. 2018 Jun 25;8:9582. doi: 10.1038/s41598-018-27964-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Partial least squares discriminant analysis of gut microbiome composition between patients with fixed airway obstruction versus no obstruction sPLS-DA plot based on the relative abundance of bacterial taxa of gut microbiota from patients with fixed airway obstruction (blue circle) or without obstruction (orange triangle) and their 95% confidence ellipses (A). Contribution plot indicating genera contributing to component 1 of the sPLS-DA plot that discriminate these phenotypes (B). The abundance of the most consistent OTUs was compared using Metagenomeseq and presented on a violin plot, which includes the median, 95% CI, IQR, and density plot where the width of the blue lines indicate frequency (C).