Table 1.
PKC binding affinities for select compounds. Values for bryostatin 1 and SUW133 are from Marsden et al. (2017). Lower Ki (nM) values indicate more effective binding. 95% confidence intervals are in parentheses.
|
PKC Ki (nM) |
|||||||
|---|---|---|---|---|---|---|---|
| α | βI | γ | δ | ε | η | θ | |
| Bryostatin 1 | 0.81 (0.6–1.1) | 2.2 (1.2–4.0) | 2.2 (1.5–3.3) | 1.1 (0.7–1.5) | 3.0 (2.1–4.2) | 2.2 (1.5–3.2) | 1.5 (1.0–2.1) |
| SUW128 | 6.1 (4.6–8.1) | 16.4 (11–25) | 48 (26–89) | 7.8 (5.5–11) | 6.8 (4.9–9.4) | 16.3 (11–25) | 6.5 (3.5–12) |
| SUW132 | 2.3 (1.4–3.8) | 6.3 (3.7–10.5) | 4.6 (3.1–6.8) | 2.9 (2.0–4.0) | 2.1 (1.2–3.7) | 1.8 (1.1–2.8) | 2.0 (1.1–3.5) |
| SUW133 | 1.8 (1.1–2.9) | 6.3 (3.5–11) | 5.6 (3.1–10) | 2.0 (1.3–3.0) | 5.8 (2.4–14) | 6.4 (3.6–10.9) | 2.0 (1.1–3.6) |