Fig. 7.

GABA_AR ion channel 2′ mutant and PS inhibition.

(A, B) Inhibition plots for GABA EC₈₀ peak (A) and steady-state (B) currents inhibited by PS at α1β2γ2L (black) and α1^V256Sβ2γ2L (green) receptors (n = 7–8). Data are presented as mean ± SEM. (C) Representative membrane currents for PS inhibition of GABA-activated currents at α1^V256Sβ2γ2L receptors. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)