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. 2018 Jun 25;8:9616. doi: 10.1038/s41598-018-28034-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mismatch-induced cortical depression in the V1. (a) Monocular prism goggle for inducing cortical depression that requires multimodal sensory mismatch between vision and whisker sensations. R represents the imaged areas, including the bilateral V1. (b) Mismatch-induced depression in a wild-type mouse. Images were obtained after removing the prism goggle. The upper two panels show bilateral cortical responses in the binocular regions of the V1 (V1B). Responses were elicited by visual stimulation to the left eye that had worn the monocular prism goggle (left) and the right naïve eye (right). The lower two panels are the responses in the monocular region of the V1 (V1M). (c) Histograms of response amplitudes of the contralateral responses in the V1B (cV1B), and ipsilateral responses in the V1B (iV1B) and V1M. (d,e) Absence of mismatch-induced depression in a Pcdh-α1,12 mouse. Data in (b) and (c) were reproduced from our previous study¹². (f,g) Ocular dominance plasticity after monocular deprivation in a Pcdh-α1,12 mouse. Significant depression was observed in the cV1B and iV1B, but not the V1M.