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. 2018 Jun 25;9:2464. doi: 10.1038/s41467-018-04815-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — SRSF5 regulates glucose metabolism and acetyl-CoA production. a Analysis of glucose consumption rate and lactate production levels in SRSF5-depleted and control A549 cells. b Analysis of glucose consumption rate and lactate production levels in SRSF5-overexpressed and control A549 cells. c Analysis of glucose consumption rate and lactate production levels in CCAR1L-depleted and control A549 cells. d Analysis of glucose consumption rate and lactate production levels in CCAR1L-overexpressed cells. e Analysis of glucose consumption rate and lactate production levels in CCAR1S-depleted and control cells. f Analysis of glucose consumption rate and lactate production levels in CCAR1S-overexpressed cells. g Measurement of glucose consumption rate and lactate production levels in the cells described in Fig. 2k. h Acetyl-CoA levels and citrate levels in SRSF5-depleted and control A549 cells in high glucose. i Acetyl-CoA levels and citrate levels in SRSF5-overexpressed and control cells. j A549 cells depleted of SRSF5 were administrated to 5 mM acetate treatment and the relative acetyl-CoA level and citrate level were monitored. k A549 cells over-expressing SRSF5 were administrated to 5 mM acetate treatment and the relative acetyl-CoA level and citrate level were monitored. Data are representative of three independent biological replicates. All data are mean and s.e.m., n = 3. *P < 0.05 and **P < 0.01 (one-way ANOVA test)