Table 3.
Association between race and TP53 expression and mutation status by technical method, CBCS3 and TCGA
| White | Black | Univariateb | Multivariate I | Multivariate II | ||||
|---|---|---|---|---|---|---|---|---|
| Method | (N,%) | (N,%) | RFD (95% CI) | p-value | RFD (95% CI) | p-value | RFD (95% CI) | p-value |
| CBCS3a | ||||||||
| IHC | ||||||||
| wild type | 490 (81.2)a | 425 (70.2)a | Ref. | Ref. | Ref. | |||
| mutant | 117 (18.8)a | 180 (29.8)a | 11.0 (7.6, 14.5) | <0.01 | 2.8 (−0.2, 5.8)c | 0.07 | −0.3 (−3.4, 2.9)e | 0.86 |
| RNA-based | ||||||||
| wild type | 316 (64.1)a | 184 (39.4)a | Ref. | Ref. | Ref. | |||
| mutant | 183 (35.7)a | 300 (60.6)a | 24.8 (20.5, 29.0) | <0.01 | 11.3 (7.6, 15.0)c | <0.01 | 3.2 (−1.6, 7.9)e | 0.19 |
| TCGA | ||||||||
| RNA-based | ||||||||
| wild type | 372 (51.2) | 51 (31.3) | Ref. | Ref. | Ref. | |||
| mutant | 354 (48.8) | 112 (68.7) | 19.9 (12.0, 27.9) | <0.01 | 19.3 (11.4, 27.3)d | <0.01 | 2.3 (−6.6, 11.2)f | 0.61 |
aPercentages weighted for sampling design, CBCS3 models adjusted for sampling weights
bUnivariate analyses restricted to same set of participants in multivariate model I
cAdjusted for age, stage and grade
dAdjusted for age and stage
eAdjusted for age, stage, grade, and PAM50 subtype
fAdjusted for age, stage, and PAM50 subtype