. 2018 Jun 25;4:13. doi: 10.1038/s41523-018-0067-5

Table 3.

Association between race and TP53 expression and mutation status by technical method, CBCS3 and TCGA

	White	Black	Univariate^b		Multivariate I		Multivariate II
Method	(N,%)	(N,%)	RFD (95% CI)	p-value	RFD (95% CI)	p-value	RFD (95% CI)	p-value
CBCS3^a
IHC
wild type	490 (81.2)^a	425 (70.2)^a	Ref.		Ref.		Ref.
mutant	117 (18.8)^a	180 (29.8)^a	11.0 (7.6, 14.5)	<0.01	2.8 (−0.2, 5.8)^c	0.07	−0.3 (−3.4, 2.9)^e	0.86
RNA-based
wild type	316 (64.1)^a	184 (39.4)^a	Ref.		Ref.		Ref.
mutant	183 (35.7)^a	300 (60.6)^a	24.8 (20.5, 29.0)	<0.01	11.3 (7.6, 15.0)^c	<0.01	3.2 (−1.6, 7.9)^e	0.19
TCGA
RNA-based
wild type	372 (51.2)	51 (31.3)	Ref.		Ref.		Ref.
mutant	354 (48.8)	112 (68.7)	19.9 (12.0, 27.9)	<0.01	19.3 (11.4, 27.3)^d	<0.01	2.3 (−6.6, 11.2)^f	0.61

^aPercentages weighted for sampling design, CBCS3 models adjusted for sampling weights

^bUnivariate analyses restricted to same set of participants in multivariate model I

^cAdjusted for age, stage and grade

^dAdjusted for age and stage

^eAdjusted for age, stage, grade, and PAM50 subtype

^fAdjusted for age, stage, and PAM50 subtype