Table 1.
Basic characteristics of investigated animals.
| LDLR−/−ApoB100/100 atherosclerotic mice | C57BL/6N control mice | Watanabe atherosclerotic rabbits | |
|---|---|---|---|
| Age, months | 6 | 9 | 45 |
| High-fat diet, months | 4 | ND | ND |
| Female/male animals, no. | 0/12 | 0/9 | 1/3 |
| Weight, g* | 37 ± 5 | 38 ± 6 | 3200 ± 800 |
| In vivo blocking study, no. | 3 | ND | ND |
| In vivo 18F-FOL PET/CT, no. | 9 + 2† | 6 | 4 |
| In vivo 18F-FDG PET/CT, no. | 8 | 4 | 4 |
| Ex vivo 18F-FOL gamma counting, no. | 9 + 3† | 9 | 4 |
| Ex vivo 18F-FOL autoradiography, no. | 8 + 2† | 6 | 4 |
| En face aorta 18F-FOL PET, no. | 1 + 1† | 1 | ND |
LDLR−/−ApoB100/100 = low-density lipoprotein receptor deficient mouse expressing only apolipoprotein B100; ND = not done; Blocking study = in vivo competition assay with 100-fold molar excess of folate glucosamine injected 1 min before 18F-FOL; no = number of investigated animals.
*Values are mean ± SD.
†No. for blocking study.