Table 3.

Quantification of ¹⁸F-FOL and ¹⁸F-FDG PET/CT in rabbit aorta.

	Global	Macrophage density*			Histopathology†
		Highest	Lowest	P ‡	Advanced	Mild	P §
RAM-11 (%)	7.8 ± 3.2║	14 ± 3.1║	3.8 ± 3.9║	0.064║	9.5 ± 4.6║	2.2 ± 1.1**	0.31║
18F-FOL (TBR¶)	2.6 ± 0.63	3.9 ± 1.8║	2.5 ± 0.20║	0.27║	2.7 ± 0.79	1.9 ± 0.47	0.023
18F-FDG (TBR¶)	1.9 ± 0.45	2.4 ± 0.15║	1.9 ± 0.55║	0.30║	1.8 ± 0.44	1.8 ± 0.38	0.76
P #	0.074	0.29║	0.15║		0.072	0.35

Results are mean ± SD (n = 4 rabbits, except ^║n = 3 and **n = 2). All P values, paired t-test.

*Based on anti-RAM-11 immunohistochemistry.

^†Based on hematoxylin-eosin staining.

^‡Highest vs. Lowest.

^§Advanced vs. Mild.

^¶Target-to-background ratio = SUV_{max, aorta}/SUV_{mean. blood}.

^#18F-FOL vs. ¹⁸F-FDG.