Table 1.
Descriptive values of the main phenotypic and genetic variables included in the analyses, stratified by genotyping platform
| Omni | Quad | 550-v1 | 550-v3 | Between-group comparison statistic (p-value)d | |
|---|---|---|---|---|---|
| Subjects (n) | |||||
| Male/female | 573/590 | 886/896 | 148/154 | 462/474 | 0.094 (0.993) |
| Medical status | |||||
| 0 /1/2/3/4 | 207/321/342/213/78 | 264/529/496/368/112 | 30/56/105/81/30 | 103/220/337/216/49 | 72.804 (10−10) |
| Age at CNBa (years) | |||||
| Median | 13 | 14 | 16 | 15 | 30.922 (<3 × 10−16) |
| Range | 8–21 | 8–21 | 8–22 | 8–21 | |
| Raw WRAT score | |||||
| Median | 54 | 55 | 57 | 55 | 7.091 (9.5 × 10−5) |
| Range | 18–70 | 16–70 | 24–69 | 11–70 | |
| Standardized WRAT score (IQ, standard units) | |||||
| Median | 106 | 105 | 106 | 105 | 4.106 (0.006) |
| Range | 64–145 | 55–145 | 71–145 | 55–145 | |
| Intracranial volume (106 mm3)b | |||||
| Median | 1.609 | 1.603 | 1.55 | 1.573 | 2.292 (0.077) |
| Range | 1.218–1.988 | 1.095–1.98 | 1.253–1.893 | 1.179–1.849 | |
| PGRSc | |||||
| Median | −3.935 × 10-3 | −3.926 × 10-3 | −3.962 × 10-3 | −3.952 × 10-3 | 7.238 (8 × 10-5) |
| Range | −4.397 × 10-3 to −3.509 × 10-3 | −4.45 × 10-3 to −3.386 × 10-3 | −4.363 × 10-3 to −3.463 × 10-3 | −4.427 × 10-3 to −3.422 × 10-3 | |
| F SNP | |||||
| Median | 0.6 × 10-3 | 0.001 | −0.9 × 10-3 | 0.7 × 10-3 | 15.315 (7 × 10-10) |
| Range | −0.017 to 0.039 | −0.023 to 0.133 | −0.019 to 0.012 | −0.018 to 0.052 | |
| F miss | |||||
| Median | 0.5 × 10-3 | 93 × 10-6 | 0.1 × 10-3 | 0.2 × 10-3 | 74.885 (<3 × 10-16) |
| Range | 0.1 × 10-3 to 5 × 10-3 | 12 × 10-6 to 0.01 | 0.02 × 10-3 to 8.9 × 10-3 | 0.01 × 10-3 to 12.8 × 10-3 | |
| N ROH | |||||
| Median | 3 | 3 | 2 | 3 | 7.63 (4 × 10-5) |
| Range | 0–19 | 0–40 | 0–12 | 0–21 | |
| F ROH | |||||
| Median | 1.652 × 10-3 | 1.603 × 10-3 | 1.331 × 10-3 | 1.438 × 10-3 | 1.659 (0.174) |
| Range | 0–41 × 10-3 | 0–127 × 10-3 | 0–12 × 10-3 | 0–49 × 10-3 | |
a Age at Computerized Neurocognitive Battery test date
b Values of estimated total intracranial volume were available only for a subset of participants (n = 385) with genetic and cognitive information included in the study (see Materials and methods—Image acquisition and pre-processing)
c Schizophrenia PGRS at the best-fitting pthreshold (0.005), as mentioned in the manuscript
d Between-group comparisons were performed using analysis of variance (ANOVA) tables for most of the variables displayed (continuous measures; F and p-values reported), except for gender and medical status, where chi-squared tests were applied on the contingency tables