Table 4.

Estimated odds ratios (OR) of CRP associated with the microbiome

Microbiome measurement (tertiles)	Range	N	OR	OR
			No adjustment	Multivariate adjusteda
LBP tertiles
1	6.8–14.9 µg/mL	36	Ref.	Ref.
2	15.0–22.1 µg/mL	37	0.96 (0.35–2.61)	0.95 (0.34–2.67)
3	22.2–94.7 µg/mL	37	2.98 (1.14–7.80)	2.09 (0.76–5.80)
			Ptrend 0.02	Ptrend 0.15
Bacteroidaceae_Bacteroides
1	0.009–0.117	37	Ref.	Ref.
2	0.118–0.216	37	2.05 (0.78–5.45)	2.21 (0.78–6.20)
3	0.234–0.562	36	2.41 (0.91–6.41)	2.52 (0.90–7.10)
			Ptrend 0.08	Ptrend 0.08
Clostridiales_Christensenellaceae_uncultured
1	0–0.004	37	Ref.	Ref.
2	0.0041–0.049	37	0.80 (0.32–2.02)	0.84 (0.32–2.20)
3	0.52–0.25	36	0.74 (0.29–1.90)	0.96 (0.35–2.61)
			Ptrend 0.53	Ptrend 0.92
Ruminococcacae _Ruminococcus
1	0–0.002	37	Ref.	Ref.
2	0.0021–0.0125	37	0.63 (0.24–1.62)	0.70 (0.26–1.89)
3	0.0125–0.063	36	0.94 (0.37–2.37)	1.23 (0.45–3.31)
			Ptrend 0.88	Ptrend 0.70
Ruminococcacae.Other
1	0.002–0.145	37	Ref.	Ref.
2	0.149–0.038	37	1.31 (0.52–3.34)	1.49 (0.55–4.04)
3	0.039–0.147	36	0.89 (0.35–2.29)	0.84 (0.31–2.29)
			Ptrend 0.81	Ptrend 0.76
Ruminococcaceae_Incertae Sedis_human gut metagenome
1	0–0.007	46	Ref.	Ref.
2	0.0009–0.008	28	2.63 (0.99–6.97)	2.94(1.02–8.42)
3	0.0081–0.14	36	1.45 (0.58–3.64)	1.50 (0.57–3.89)
			Ptrend 0.38	Ptrend 0.37
Ruminococcaceae__Oscillibacter
1	0	57	Ref.	Ref.
2	0.0008–0.004	17	1.66 (0.56–4.94)	1.59 (0.50–5.01)
3	0.0041–0.41	36	0.65 (0.27–1.58)	0.54 (0.21–1.38)
			Ptrend 0.41	Ptrend 0.24
Ruminococcaceae__Subdoligranulum
1	0–0.0095	37	Ref.	Ref.
2	0.0096–0.021	37	1.26 (0.49–3.30)	1.31 (0.47–3.60)
3	0.022–0.14	36	1.86 (0.72–4.82)	1.92 (0.71–5.21)
			Ptrend  0.20	Ptrend 0.20
Ruminococcaceae__Uncultured
1	0–0.008	37	Ref.	Ref.
2	0.005–0.025	37	1.12 (0.44–2.82)	1.25 (0.47–3.35)
3	0.027–0.13	36	0.73 (0.28–1.90)	0.84 (0.31–2.31)
			Ptrend  0.53	Ptrend 0.75
Veillonellaceae__Phascolarctobacterium
1	0	49	Ref.	Ref.
2	0.001–0.006	25	0.69 (0.26–1.84)	0.69 (0.24–1.94)
3	0.0061–0.026	36	0.35 (0.14–0.89)	0.30 (0.11–0.81)
			Ptrend  0.03	Ptrend 0.02
Porphyromonadaceae_Barnesiella
1	0	50	Ref.	Ref.
2	0.001–0.0046	24	0.98 (0.37–2.64)	0.97 (0.34–2.8)
3	0.0047–0.04	36	0.69 (0.28–1.68)	0.54 (0.21–1.40)
			Ptrend  0.43	Ptrend  0.22

^aAdjusted for age, physical activity, and smoking history