Table 3.
Performance of CKD-EPI GFR estimating equations overall and by race and sex subgroups
| Equation | Subgroup | Bias | Precision | Accuracy (error rate) |
|
|---|---|---|---|---|---|
| Median difference mGFR − eGFR (95% CI) | IQR difference mGFR − eGFR (95% CI) | 1 P30% eGFR > 30% of mGFR (95% CI) | Root mean square error (95% CI) | ||
| CKD-EPI creatinine | Overall | −8.3 (−9.7, −6.5) | 17.6 (15.2, 19.5) | 19.0 (14.6, 23.5) | 0.203 (0.186, 0.218) |
| White female | −12.3 (−15.8, −8.3) | 15.7 (11.2, 18.5) | 30.0 (18.6, 41.4) | 0.220 (0.188, 0.251) | |
| Back female | −16.4 (−18.9, −12.4) | 16.0 (11.6, 21.4) | 34.3 (24.3, 45.7) | 0.261 (0.226, 0.296) | |
| White male | −1.6 (−6.2, 0.8) | 17.6 (12.6, 20.4) | 7.1 (2.4, 12.9) | 0.159 (0.136, 0.182) | |
| Black male | −5.8 (−7.4, −2.4) | 13.3 (9.6, 16.9) | 7.2 (1.4, 13.0) | 0.160 (0.132, 0.186) | |
| CKD-EPI cystatin C | Overall | −3.7 (−5.0, −1.8) | 18.0 (16.1, 20.9) | 11.2 (7.8, 15.0) | 0.190 (0.175, 0.207) |
| White female | −5.0 (−11.4, −2.8) | 18.7 (14.4, 23.5) | 15.7 (7.1, 24.3) | 0.199 (0.176, 0.223) | |
| Back female | −5.0 (−9.5, −2.5) | 18.0 (12.3, 22.0) | 11.4 (4.3, 18.6) | 0.183 (0.156, 0.209) | |
| White male | 1.8 (−3.3, 5.4) | 18.1 (14.2, 23.3) | 8.2 (3.5, 14.1) | 0.194 (0.156, 0.236) | |
| Black male | −4.3 (−8.1, 0.1) | 15.4 (10.6, 20.7) | 10.1 (4.3, 17.4) | 0.184 (0.150, 0.217) | |
| CKD-EPI creatinine– cystatin C | Overall | −7.8 (−9.2, −6.2) | 14.0 (12.1, 16.2) | 12.6 (8.8, 16.3) | 0.176 (0.163, 0.188) |
| White female | −9.8 (−12.2, −6.7) | 14.2 (9.8, 16.7) | 17.1 (8.6, 26.4) | 0.185 (0.162, 0.206) | |
| Back female | −13.5 (−16.9, −9.5) | 15.6 (11.7, 19.0) | 27.1 (17.1, 37.1) | 0.220 (0.194, 0.246) | |
| White male | −2.7 (−4.6, 0.3) | 13.4 (10.6, 17.4) | 1.2 (0.0, 3.5) | 0.130 (0.111, 0.150) | |
| Black male | −7.3 (−9.6, −4.3) | 12.8 (8.4, 15.7) | 7.2 (1.4, 13.0) | 0.164 (0.138, 0.188) | |