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. 2018 Jun 26;8:9714. doi: 10.1038/s41598-018-27822-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Location of R1451 in the “up” conformation of Na_V1.4 VSD-IV. In the cryo-EM structure of electric eel Na_V1.4 (protein data bank ID 5XSY) the residue corresponding to Na_V1.4-R1451 (blue spheres) is located in proximity to the residue corresponding to Na_V1.4-E1373 (pink spheres) in the S1-S2 loop of VSD-IV. The distance between the guanidino- and delta-carbons of R1451 and E1373, respectively, is 5.78 Å. Arginines corresponding to R1448, R1454 and R1457 are shown in blue sticks. The structure is illustrated with the PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC.