Table 8.

Relative risk of major and non-major bleeding using direct oral anticoagulants compared with Vitamin K antagonist

Study	Drug	Risk ratio of major and clinically relevant non-major bleeding events
RE-COVER (2009)	Dabigatran	0.64 (0.48–0.85)
RE-COVER II (2014)	Dabigatran	0.63 (0.47–0.86)
EINSTEIN-DVT (2010)	Rivaroxaban	1.00 (0.80–1.25)
EINSTEIN PE (2012)	Rivaroxaban	0.91 (0.77–1.07)
AMPLIFY study (2013)	Apixaban	0.44 (0.36–0.55)
HOKUSAI-VTE (2013)	Edoxaban	0.83 (0.72–0.95)

DVT, deep vein thrombosis; VTE, venous thromboembolism.