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. 2018 Jun 22;13:3593–3608. doi: 10.2147/IJN.S160828

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© 2018 Fu et al. This work is published and licensed by Dove Medical Press Limited

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Effects of SiO₂-NP exposure on anxiety-like and depressive-like behaviors.

Notes: (A) Percentage of time spent in the open arm, (B) percentage of entries into open arm in the plus maze are shown, (C) time in the light side of chamber, and (D) total number of transitions between the light and dark side of chamber. SiO₂-NP exposure did not result in significant differences in immobility times in the last 4 min of the (E) FST or (F) TST. All results are presented as the mean ± SEM (n=11 for vehicle, n=9 for the SiO₂-NP-treated group); ^*p<0.05.

Abbreviations: SiO₂-NPs, silica nanoparticles; SEM, standard error of the mean; FST, forced swimming test; TST, tail suspension test.

Effects of SiO₂-NP exposure on anxiety-like and depressive-like behaviors.

Notes: (A) Percentage of time spent in the open arm, (B) percentage of entries into open arm in the plus maze are shown, (C) time in the light side of chamber, and (D) total number of transitions between the light and dark side of chamber. SiO₂-NP exposure did not result in significant differences in immobility times in the last 4 min of the (E) FST or (F) TST. All results are presented as the mean ± SEM (n=11 for vehicle, n=9 for the SiO₂-NP-treated group); ^*p<0.05.

Abbreviations: SiO₂-NPs, silica nanoparticles; SEM, standard error of the mean; FST, forced swimming test; TST, tail suspension test.