Table 2.
Prevalence of Asthma by TSB Level at 48 Hours Postpartum and Maximum TSB Level and Odds Ratios in the Collaborative Perinatal Project, United States, 1959–1965
| TSB, mg/dL | No. (Total n = 28,807) | No. of Asthma Cases (Total n = 1,514) | Prevalence of Asthma, %a | Crude Analysis |
Adjusted Analysisb |
Trend Analysisc |
|||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | Adjusted OR | 95% CI | P Value | Adjusted P Value | ||||
| 48-Hour level | 0.0045 | 0.0093 | |||||||
| ≤3 | 5,945 | 286 | 4.81 | 1.00 | Referent | 1.00 | Referent | ||
| 3.1–6 | 9,754 | 490 | 5.02 | 1.05 | 0.85, 1.38 | 1.07 | 0.92, 1.26 | ||
| 6.1–9 | 8,747 | 492 | 5.62 | 1.19 | 1.05, 1.36 | 1.23 | 1.05, 1.44 | ||
| 9.1–15 | 4,089 | 224 | 5.48 | 1.15 | 1.03, 1.28 | 1.17 | 1.02, 1.33 | ||
| >15 | 272 | 22 | 8.09 | 1.68 | 1.11, 2.25 | 1.59 | 0.89, 2.30 | ||
| Maximum level | 0.0022 | 0.0078 | |||||||
| ≤3 | 5,792 | 269 | 4.64 | 1.00 | Referent | 1.00 | Referent | ||
| 3.1–6 | 9,572 | 477 | 4.98 | 1.08 | 0.91, 1.25 | 1.08 | 0.93, 1.27 | ||
| 6.1–9 | 8,443 | 475 | 5.63 | 1.20 | 1.15, 1.82 | 1.22 | 1.04, 1.42 | ||
| 9.1–15 | 4,099 | 221 | 5.39 | 1.17 | 0.96, 1.42 | 1.19 | 0.91, 1.46 | ||
| >15 | 901 | 72 | 7.99 | 1.70 | 1.07, 2.45 | 1.61 | 1.04, 2.08 | ||
Abbreviations: CI: confidence interval; OR, odds ratio; TSB, total serum bilirubin.
a Overall prevalence of asthma = 5.26%.
b Generalized estimating equation model adjusted for maternal race, sex, gestational age, and study center with family number as repeated subject.
c Trend analysis adjusted for maternal race, sex, gestational age, and study center.