. 2018 Jun 20;12:1799–1807. doi: 10.2147/DDDT.S152659

Table 3.

Comparison of plasma C_max and AUC_0–24 for Japanese vs non-Asian subjects following single or multiple verinurad 10 mg doses

Treatment	Parameter	Japanese	Non-Asian	GMR, % (95% CI)	Bodyweight normalized to 70 kg
Treatment	Parameter	Japanese	Non-Asian	GMR, % (95% CI)	Japanese	Non-Asian	GMR, % (95% CI)
Single dose, fasted	C_max, ng/mL	21.9	11.0	199 (167–237)	20.6	13.1	157 (132–187)
Single dose, fasted	AUC_0–24, ng·h/mL	93.4	69.9	134 (111–161)	87.9	83.3	106 (84.5–132)
Single dose, fed	C_max, ng/mL	21.9	15.4	142 (107–189)	20.6	18.3	112 (88.5–143)
Single dose, fed	AUC_0–24, ng·h/mL	195	111	176 (137–227)	183	132	139 (114–170)
Multiple dose, fed	C_max, ng/mL	24.9	18.0	138 (112–171)	23.4	21.5	109 (94.4–126)
Multiple dose, fed	AUC_0–24, ng·h/mL	173	141	123 (93.0–162)	163	168	96.9 (77.4–121)

Notes: Data are geometric least square means. GMR, Japanese/non-Asian.

Abbreviations: C_max, maximum plasma concentration; AUC_0–24, area under verinurad concentration–time curve from 0 to 24 hours; GMR, geometric mean ratio; PK, pharmacokinetics.