Table 1.

Guidelines for the Reporting of Adaptive Trials^a

Describe	The adaptation Whether the adaptation was planned or unplanned The rationale for the adaptation When the adaptation was made The data on which adaptation is based and whether the data were unblinded The planned process for the adaptation including who made the decision regarding adaptation Deviations from the planned process Consistency of results before vs after the adaptation
Discuss	Potential biases induced by the adaptation Adequacy of firewalls to protect against operational bias The effects on error control and multiplicity context

^aAdapted from Evans and Ting [14].