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. 2018 Jan 15;217(8):1231–1236. doi: 10.1093/infdis/jiy022

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Published by Oxford University Press for the Infectious Diseases Society of America 2018.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 3. — Low but measurable pertussis toxin (PT) titers correlate with protection. Serum samples were collected from infants immediately prior to challenge. Immunoglobulin G antibodies to the 4 vaccine antigens present in licensed acellular pertussis vaccines—PT, filamentous hemagglutinin (FHA), pertactin (PRN), and fimbriae (FIM)—were measured by an enzyme-linked immunosorbent assay. Red symbols represent animals with significant clinical signs of disease. Black symbols represent animals without outward signs of disease. Triangles represent animals born to vaccinated mothers. Circles represent animals born to unvaccinated animals.