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. 2018 Jun 26;7:e34135. doi: 10.7554/eLife.34135

Figure 4. Rescue of the auditory-cued fear memory deficit in LAGRKO mice by restoring GR expression levels in the LA.

Figure 4.

(A) The experimental protocol for adeno-associated virus (AAV) vector injection and fear conditioning. (B) Representative images of the expression of green fluorescent protein (GFP, green) and GR (magenta) in the LA of LAGRKO mice injected with AAV-GFP or AAV-GR. The expression levels of GFP and GR were assessed after the behavioral test was completed. Freezing levels during the training (C), contextual test (D), and cued test (E). During the cued test, LAGRKO mice (n = 9) injected with AAV-GR and floxed GR injected with AAV-GFP exhibited significantly higher levels of freezing in the presence of the tone than did AAV-GFP-injected LAGRKO mice (n = 9). There were no significant differences between the three groups during the training and contextual tests. Data are presented as mean ± S. E. M. *p<0.05.

Figure 4—source data 1. Raw data for generating Figure 4B–E.
elife-34135-fig4-data1.xlsx (15.5KB, xlsx)
DOI: 10.7554/eLife.34135.012