Table 3. Hazard ratios (95% CI) for the relationship between the ERDP score and postmenopausal breast cancer in PLCO.
| ERDP quartiles | Estimate for continuous ERDP scorea, p-trend | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| 1st | 2nd | 3rd | 4th | |||
| Total breast cancer | ||||||
| No. of cases | 366 | 392 | 403 | 431 | ||
| Age-adjusted | 1.00 (ref) | 1.07 (0.93, 1.24) | 1.10 (0.95, 1.26) | 1.18 (1.03, 1.36) | 1.12 (1.03, 1.20) p=0.005 | |
| Age- and-TEI adjusted | 1.00 (ref) | 1.09 (0.94, 1.25) | 1.10 (0.95, 1.27) | 1.15 (1.00, 1.33) | 1.10 (1.01, 1.18) p=0.02 | |
| Multivariable-adjustedb | 1.00 (ref) | 1.08 (0.94, 1.25) | 1.10 (0.95, 1.27) | 1.14 (0.98, 1.32) | 1.09 (1.01, 1.18) p=0.04 | |
| Invasive | ||||||
| No. of cases | 280 | 309 | 331 | 348 | ||
| Age-adjusted | 1.00 (ref) | 1.11 (0.94, 1.30) | 1.18 (1.00, 1.38) | 1.25 (1.07, 1.47) | 1.16 (1.07, 1.26) p=0.0006 | |
| Age- and-TEI adjusted | 1.00 (ref) | 1.12 (0.95, 1.32) | 1.18 (1.01, 1.38) | 1.21 (1.03, 1.43) | 1.14 (1.04, 1.24) p=0.003 | |
| Multivariable-adjustedb | 1.00 (ref) | 1.12 (0.95, 1.31) | 1.18 (1.01, 1.39) | 1.20 (1.02, 1.42) | 1.13 (1.04, 1.24) p=0.005 | |
| ER+ | ||||||
| No. of cases | 246 | 275 | 274 | 302 | ||
| Age-adjusted | 1.00 (ref) | 1.12 (0.94, 1.33) | 1.11 (0.93, 1.32) | 1.23 (1.04, 1.46) | 1.15 (1.05, 1.26) p=0.003 | |
| Age- and-TEI adjusted | 1.00 (ref) | 1.13 (0.95, 1.35) | 1.11 (0.94, 1.32) | 1.20 (1.01, 1.42) | 1.13 (1.03, 1.24) p=0.01 | |
| Multivariable-adjustedb | 1.00 (ref) | 1.13 (0.95, 1.34) | 1.11 (0.94, 1.32) | 1.19 (0.99, 1.41) | 1.13 (1.02, 1.24) p=0.02 | |
| ER- | ||||||
| No. of cases | 45 | 41 | 55 | 48 | ||
| Age-adjusted | 1.00 (ref) | 0.92 (0.60, 1.40) | 1.21 (0.82, 1.80) | 1.06 (0.71, 1.59) | 1.09 (0.87, 1.35) p=0.46 | |
| Age- and-TEI adjusted | 1.00 (ref) | 0.93 (0.61, 1.43) | 1.22 (0.82, 1.81) | 1.01 (0.66, 1.53) | 1.06 (0.85, 1.32) p=0.63 | |
| Multivariable-adjustedb | 1.00 (ref) | 0.94 (0.61, 1.44) | 1.24 (0.83, 1.84) | 1.04 (0.68, 1.59) | 1.07 (0.85, 1.35) p=0.54 | |
| Person-years accumulated | 74,615 | 74,375 | 74,932 | 74,468 | ||
ERDP: estrogen related dietary pattern; TEI: total energy intake; ER: estrogen receptor; BMI: body mass index; PHT: postmenopausal hormone therapy; PA: physical activity; PLCO: Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
a
HR corresponds to 1-unit increase in ERDP score
b
Includes adjustment for age, TEI, BMI, BMI at age 20, PHT, alcohol use, education, bilateral oophorectomy, parity, age at menopause, PA, race/ethnicity, recruitment center, and family history of breast cancer.