Table 1.
All-Patient Comparison of Clinical Correlates and Outcome Variables by high-dose aspirin (HDA) group
| HDA Duration Group | |||||
|---|---|---|---|---|---|
| Variable | Statistics/ Category | 0 day (N =17) | 1–7 day (N =63) | > 7 day (N =23) | P- value |
| Age at diagnosis, years | Mean(SD) | 6.56 (5.89) | 4.19 (3.61) | 4.24 (3.92) | 0.10 |
| Age range at diagnosis | < 1 year(%) | 3 (18) | 11 (17) | 3 (13) | 0.12 |
| 1–5 years(%) | 5 (29) | 34 (54) | 16 (70) | ||
| > 5 years(%) | 9 (53) | 18 (29) | 4 (17) | ||
| Sex | Male (%) | 11 (65) | 34 (54) | 18 (78) | 0.12 |
| Female(%) | 6 (35) | 29 (46) | 5 (22) | ||
| Race | White (%) | 11 (65) | 41 (65) | 16 (70) | 0.76 |
| Black (%) | 3 (18) | 6 (10) | 1 (4) | ||
| Asian (%) | 1 (6) | 6 (10) | 3 (13) | ||
| Hispanic (%) | 2 (12) | 8 (13) | 1 (4) | ||
| Other (%) | 0 (0) | 2 (3) | 2 (9) | ||
| Yes (%) | 10 (59) | 40 (69) | 11 (50) | ||
| Classic KD | No (%) | 7 (41) | 18 (31) | 11 (50) | 0.27 |
| Unknown | 0 | 5 | 1 | ||
| Illness duration before diagnosis, days | Mean (SD) | 23 (16.87)a,b | 8.23 (5)a | 10.86 (5)b | <0.001 |
| Defervescence duration before diagnosis, days | Mean (SD) | 11.76 (13.47)a,b | 0.46 (2.55)a | 0.24 (0.70)b | <0.001 |
| CAAs at diagnosis | Yes (%) | 7 (41) | 18 (29) | 10 (43) | 0.34 |
| No (%) | 10 (59) | 45 (71) | 13 (57) | ||
| CRP at diagnosis, g/dL | Mean (SD) | 6.87 (5.24) | 11.93 (9.15) | 9.76 (7.29) | 0.19 |
| Platelet count at diagnosis, x109/L | Mean (SD) | 543.1 (403.5) | d 373 (170.3)d | 485.5 (202.8)d | 0.03 |
| IVIg #1 given | Yes (%) | 11 (65)a,b | 62 (98)a | 23 (100)b | <0.001 |
| No (%) | 6 (35) | 1 (2) | 0 (0) | ||
| IVIg Resistance | Yes (%) | 5 (45) | 14 (23) | 10 (43) | 0.08 |
| No (%) | 6 (55) | 48 (77) | 13 (57) | ||
| Unknown | 6 | 1 | 0 | ||
| Fever duration after diagnosis, days | Mean(SD) | 0.13 (0.50) | 1.16 (3.30) | 2.41 (5.09) | 0.14 |
| CRP at 4–8 weeks, g/dL | Mean(SD) | 0.69 (0.58) | 0.32 (0.22) | 0.66 (0.61) | 0.05 |
| CRP at 9–15 months, g/dL | Mean(SD) | 0.96 (1.10) | 0.57 (0.13) | 0.34 (0.11) | 0.42 |
| Platelet count at 4–8 weeks, x 109/L | Mean (SD) | 319.9 (127.8) | 358.3 (115.2) | 394.3 (110.2) | 0.32 |
| Platelet count at 9–15 months, x 109/L | Mean (SD) | 388.3 (145.5) | 283.3 (106.5) | 264.4 (59.8) | 0.08 |
Superscripts denote pairwise comparisons of statistical significance for variables with P-values < 0.05, a for a significant difference between the 0 day HDA group and the 1–7 day HDA group, b for a significant difference between the 0 day HDA group and the > 7 day HDA group, c for a significant difference between the 1–7 day HDA group and the > 7 day HDA group, and d for no significant differences in pairwise comparison. Bonferroni’s adjustment for multiple comparisons is used, whereby a P-value threshold for statistical significance between pairs is 0.05/(number of pairwise comparisons) = 0.05/3 = 0.0167. CAA = Coronary Artery Abnormality, CRP = C-Reactive Protein, HDA = High-Dose Aspirin, IVIg = Intravenous Immunoglobulin, KD = Kawasaki Disease, SD = Standard Deviation.