Table 2.

Imprinted gene DMR^§ methylation distributions in 164 CIN1 patients at Enrollment^*

Gene Name	CpG site	N†	Mean	Median	SD‡	Interquartile Range	Range
IGF2AS	5	157	0.47	0.58	0.32	0.57	(0.00, 0.96)
Kv
	DMR§	144	0.30	0.29	0.05	0.07	(0.16, 0.42)
	1	143	0.25	0.26	0.06	0.07	(0.12, 0.39)
	6	144	0.25	0.26	0.06	0.08	(0.08, 0.41)
	8,9	144	0.27	0.27	0.05	0.07	(0.03, 0.40)
	10,11,12	142	0.23	0.23	0.06	0.07	(0.03, 0.38)
	15	144	0.30	0.31	0.06	0.08	(0.14, 0.43)
	17,18	144	0.30	0.31	0.05	0.07	(0.14, 0.49)
	20	144	0.31	0.31	0.06	0.06	(0.10, 0.47)
	21	144	0.30	0.30	0.06	0.05	(0.12, 0.47)
	22	144	0.24	0.24	0.04	0.04	(0.12, 0.43)
	24	144	0.29	0.30	0.08	0.10	(0.11, 0.44)
	26,27	144	0.55	0.55	0.06	0.07	(0.35, 0.70)
MEG3‖
	DMR§	152	0.49	0.52	0.11	0.19	(0.26, 0.82)
	3	152	0.57	0.59	0.16	0.17	(0.11, 1.00)
	6	150	0.54	0.54	0.09	0.28	(0.31, 0.96)
	15	152	0.40	0.39	0.10	0.14	(0.00, 0.80)
	16	150	0.38	0.38	0.10	0.15	(0.00, 0.82)
	20,21	150	0.43	0.42	0.09	0.14	(0.05, 0.75)
	22	150	0.54	0.54	0.09	0.17	(0.31, 0.96)
	23	152	0.46	0.46	0.10	0.14	(0.21, 0.95)
	26,27,28	152	0.55	0.55	0.11	0.21	(0.03, 0.89)
	29,30,31	152	0.57	0.56	0.12	0.19	(0.12, 1.00)
PEG10
	DMR§	140	0.30	0.32	0.08	0.07	(0.00, 0.45)
	5	137	0.31	0.32	0.10	0.07	(0.02, 0.83)
	6	138	0.26	0.27	0.12	0.14	(0.00, 0.47)
	7	139	0.32	0.34	0.10	0.07	(0.00, 0.85)

^*CIN = Cervical Intraepithelial Neoplasia; CINCS = Cervical Intraepithelial Neoplasia Cohort Study

^†Numbers do not add up to the total sample size due to missing data

^‡SD = Standard Deviation

^§DMR = Differentially methylated region; Median across all CpG loci for candidate gene

^‖MEG3 intronic differentially methylated region