Table 4.

Analysis of CIN Regression Imprinted Gene DMRs among CIN1 cases in North Carolina: Stratified by Age at Enrollment^*

Gene	CpG Site	Overall	Age <25 years N=56	Age ≥25 years N=78
		HR (95% CI)†‡
IGFAS	5	0.41 (0.23, 0.76)	0.41 (0.17, 0.97)	0.65 (0.34, 1.25)
Kv	DMR§	0.83 (0.55, 1.26)	0.73 (0.40, 1.34)	0.86 (0.52, 1.41)
MEG3	DMR§	0.89 (0.57, 1.38)	1.53 (0.80, 2.94)	0.54 (0.32, 0.92)
PEG10	DMR§	0.80 (0.65, 0.98)	0.60 (0.43, 0.85)	0.88 (0.69, 1.12)

^*CIN = cervical intraepithelial neoplasia; 151 cases with at least one follow-up visit

^†HR=Hazard ratio; 95% CI= 95% confidence intervals; continuous methylation levels rescaled using interquartile range for each CpG site

^‡Adjusted for race, current smoking, continuous parity and history of oral contraceptive use

^§DMR = differentially methylated region (median of all CpG sites

^‖MEG3 intronic differentially methylated region