Table 1.
Baseline clinical and laboratory characteristics of study participants.
| Characteristic | Value |
|---|---|
| Age (yr) | 22.9 ± 9 |
| BSA (m2) | 1.67± 0.37 |
| Female, n (%) | 12 (60) |
| Receiving hydroxyurea, n (%) | 15 (75) |
| Baseline Heart rate (bpm) | 73 ± 14 |
| Systolic blood pressure (mmHg) | 118 ± 12 |
| Diastolic blood pressure (mmHg) | 67 ± 8 |
| White blood cell count (103/mm3) | 9.6 ± 3.7 |
| Hemoglobin (g/dL) | 9.9 ± 1.6 |
| Hematocrit (%) | 28.1 ± 4.3 |
| Reticulocyte count (%) | 6.3 (4.8–10.8) |
| Platelet count (103/mm3) | 350 ± 96 |
| Bilirubin (mg/dL) | 2.1 (1.5–2.8) |
| AST (unit/L) | 49 ± 29 |
| LDH (unit/L) | 560 ± 275 |
| Plasma free hemoglobin (mg/dL) | 21.1(11.1–90.1) |
| Nucleated RBC (cell/100 WBC) | 0.5(0.1–3.75) |
| Fetal hemoglobin (%) | 16.8 ± 13.6 |
| Mean corpuscular volume (fL) | 92.4 ± 19.8 |
| Absolute neutrophil count (K/uL) | 4.8 ± 2.5 |
| Creatinine (mg/dL) | 0.56 ± 0.17 |
| Cystatin C (mg/L) | 0.64 ± 0.14 |
| GFR (mL/min/1.73 m2) | 145 ± 38 |
| NT-proBNP (pg/mL) | 41(22–131) |
| FEV1 (%) | 82 ± 14 |
| FVC (%) | 88 ± 13 |
| FEV1/FVC (%) | 93 ± 9 |
| RLD (FVC<80%), n (%) | 6(30%) |
| OLD (FEV1/FVC<80%), n (%) | 1(5%) |
| Native T1 (ms) | 1001 ± 68 |
| ECV | 0.43 ± 0.08 |
The values are reported as mean ± standard deviation or median (interquartile range). AST: aspartate aminotransferase, ECV: extracellular volume, fl: femtoliter, FEV1: forced expiratory volume in the first second, FVC: forced vital capacity, GFR: glomerular filtration rate, LDH: lactate dehydrogenase, OLD: obstructive lung disease, RBC: red blood cell, RLD: Restrictive lung disease, VO2: oxygen consumption, VCO2: carbon dioxide production, Yr: Year.