TABLE 3.

RV Invasive Pressure-Volume Loop Measurements^*

	Saline		AAV1.SERCA2a		p Value†
	Baseline (n = 10)	Final (n = 6)	Baseline (n = 10)	Final (n = 8)	Baseline	Group/Time Interaction
PA Ea, mm Hg/ml	1.25 (0.96 to 1.54)	1.88 (1.09 to 2.09)	1.02 (0.81 to 1.32)	0.81 (0.61 to 0.96)	0.653	0.005
ESPVR slope, mm Hg/ml	1.13 (0.64 to 1.40)	0.92 (0.74 to 1.40)	0.77 (0.63 to 1.15)	0.63 (0.53 to 0.76)	0.216	0.043
Vo, ml	−4.9 (−18.3 to 2.1)	−14 (−30.3 to 5.2)	−10.5 (−18.2 to 2.3)	−24.8 (−37.1 to 3.8)	0.856	0.6
ESPVR/Ea	0.84 (0.69 to 1.18)	0.72 (0.57 to 0.84)	0.74 (0.62 to 0.97)	0.97 (0.72 to 1.08)	0.434	0.167
dP/dt max, mm Hg/s	624 (591 to 800)	764 (690 to 875)	662 (493 to 731)	690 (671 to 861)	0.551	0.84
EDPVR slope, mm Hg/ml	0.21 (0.17 to 0.32)	0.28 (0.23 to 0.30)	0.27 (0.20 to 0.37)	0.12 (0.10 to 0.18)	0.391	0.006
dP/dt min, mm Hg/s	−623 (−732 to −468)	−907 (−1,039 to −629)	−486 (−628 to −406)	−560 (−626 to −474)	0.372	0.097
Tau, ms	33 (26 to 41)	37 (34 to 40)	33 (31 to 37)	34 (32 to 36)	0.301	0.423

Values are median (IQR).

^*Baseline was at 2 months after model creation and final was at 4 months after model creation (and 2 months after gene transfer).

^†Independent samples Student t test.

dP/dt = peak RV pressure rate of rise (max) or decline (min); Ea = arterial elastance; EDPVR = end-diastolic pressure–volume relationship; ESPVR = end-systolic pressure–volume relationship; PA = pulmonary artery; Tau = time constant of isovolumic relaxation; Vo = volume intercept of the ESPVR slope; other abbreviations as in Tables 1 and 2.