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. Author manuscript; available in PMC: 2018 Jun 26.
Published in final edited form as: ACS Nano. 2018 Mar 20;12(4):3378–3384. doi: 10.1021/acsnano.7b08965

Figure 3. IL-3 as a biomarker for sepsis detection.

Figure 3

Patient samples (23 from septic and 39 from non-septic patients) were analyzed with the IBS assay. (A) A waterfall plot shows the IL-3 levels measured by the IBS system. Each column represents a different sample (red, septic; grey, non-septic). (B) IL-3 level was higher in septic patients than in non-septic controls (P < 0.0001, unpaired t-test). (C) A receiver-operation characteristic curve was constructed. The area under the curve (AUC) was 0.91 with IBS and 0.73 with ELISA. The optimum threshold value that maximized both sensitivity and specificity was [IL-3] = 21.7 pg/mL.