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. 2018 Jun 25;18:687. doi: 10.1186/s12885-018-4597-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Differential transcription of genes encoding HSPGs. a, b, Relative transcript abundance of mRNAs for healthy tissues (gray bars) and tumors (black bars). Genes that show significant differences in their transcription levels are highlighted. a, Non-metastatic LSCRCs. 1: syndecan-1 (p < 0.05); 4: perlecan (p < 0.05); 5: collagen XVIII (p < 0.05); serglycin (p < 0.05). b, Metastatic LSCRCs. 1: syndecan-1 (p < 0.035); 2: glypican-4 (p < 0.05); 3: glypican-6 (p < 0.05); 4: perlecan (p < 0.05); 8: serglycin (p < 0.05). c, Relative expression ratio of genes that show statistically significant differences in expression in non-metastatic (●) or metastatic (■) CRCs. Values on the Y axis are on a logarithmic scale and the spreads represent the standard deviations