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. 2018 Jun 25;18:687. doi: 10.1186/s12885-018-4597-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Transcription of genes encoding the glycosyltransferases involved in the biosynthesis of HS and CS chains. a, b, Relative transcript abundance of mRNAs for healthy tissues (gray bars) and tumors (black bars). Genes that display significant differences in their transcription levels are highlighted. a, Non-metastatic LSCRCs. 1: N-acetylgalactosaminyltransferase 2 (p < 0.05); 2: chondroitin polymerizing factor (p < 0.05). b, Metastatic LSCRCs. 2: chondroitin polymerizing factor (p < 0.05). c, Relative expression ratio of genes that showed statistically significant differences in expression in non-metastatic (●) and metastatic (■) LSCRCs. Values on the Y axis are on a logarithmic scale and the spreads represent the standard deviations