Fig. 8.

Differential transcription of genes involved in the modification of CS chains. a, b, Relative transcript abundance of mRNAs for healthy tissue (gray bars) and tumors (black bars. Genes that display significant differences in their transcription levels are highlighted. a, Non-metastatic LSCRCs. 1: chondroitin 4 sulfotransferase 1 (p < 0.05); 2: chondroitin 4 sulfotransferase 2 (p < 0.05); 3: chondroitin 6 sulfotransferase 1 (p < 0.05); 5: dermatan sulfate epimerase (p < 0.05); 6: uronyl-2-sulfotransferase (p < 0.01). b, Metastatic LSCRCs. 1: chondroitin 4 sulfotransferase 1 (p < 0.05); 2: chondroitin 4 sulfotransferase 2 (p < 0.05); 4: chondroitin 6 sulfotransferase 2 (p < 0.01); 6: uronyl-2-sulfotransferase (p = 0.012). c, Relative expression ratio of genes that show statistically significant differences in expression in non-metastatic (●) and metastatic (■) LSCRCs. Values on the Y axis are on a logarithmic scale and the spreads represent the standard deviations