FIG. 3.

Typical organ-on-a-chip devices containing two adjacent channels separated by a semi-permeable membrane. (I) Device of Achyuta et al. that consists of 2 parts which are assembled following the cell seeding. [Reproduced with permission from Achyuta et al., Lab Chip 13, 542 (2012). Copyright 2012 The Royal Society of Chemistry.] (II) Device of Huh et al. that consists of two adjacent channels separated by a porous PDMS membrane. [Reproduced with permission from Huh et al., Science 328, 1662 (2010). Copyright 2010 American Association for the Advancement of Science.] (III) Design of Kim et al. that contains two channels, one of which seeded with gut epithelial cells, other containing the interstitial fluid. [Reproduced with permission from Kim et al., Lab Chip 12, 2165 (2012). Copyright 2012 The Royal Society of Chemistry.]