Table 2. Genotype frequency distributions of DROSHA and DGCR8 SNPs in included studies.

Ref. No.	Year	Cancer type	Gene	SNPs1	Sample size		Case			Control			PHWE	MAF in controls (Global MAF4)	Included in meta-analysis
Case	Control	Homozygote wild	Heterozygote	Homozygote variant	Homozygote wild	Heterozygote	Homozygote variant
1	2010	Lung cancer	DROSHA	rs6877842	93	93	81	11	1	84	8	1	0.136	0.054 (0.138)	Yes
				(G > C)
		Lung cancer	DROSHA	rs10719	97	97	59	29	9	52	38	7	0.987	0.268 (0.483)	Yes
				(T > C)
		Lung cancer	DGCR8	rs3757	94	90	60	27	7	60	24	6	0.114	0.200 (0.182)	Yes
				(G > A)
		Lung cancer	DGCR8	rs417309	98	97	90	8	0	88	9	0	0.632	0.046 (0.043)	Yes
				(G > A)
		Lung cancer	DGCR8	rs1640299	98	97	58	33	7	52	40	5	0.444	0.258 (0.381)	Yes
				(T > G)
2	2013	Breast cancer	DROSHA	rs10719	847	878	433	346	68	463	353	62	0.635	0.272 (0.483)	Yes
				(T > C)
		Breast cancer	DROSHA	rs17409893	849	885	527	287	35	575	276	34	0.902	0.194 (0.222)	No3
				(A > G)
		Breast cancer	DROSHA	rs2291109	858	886	552	273	33	535	306	45	0.884	0.223 (0.061)	Yes
				(A > T)
		Breast cancer	DROSHA	rs642321	854	883	212	423	219	231	433	219	0.571	0.493 (0.322)	Yes
				(C > T)
		Breast cancer	DGCR8	rs1640299	849	891	465	330	54	476	357	58	0.412	0.265 (0.381)	Yes
				(T > G)
		Breast cancer	DGCR8	rs417309	860	893	771	89	0	826	67	0	0.244	0.038 (0.043)	Yes
				(G > A)
		Breast cancer	DGCR8	rs720012	867	891	225	425	217	240	451	200	0.668	0.478 (0.221)	No3
				(G > A)
		Breast cancer	DGCR8	rs720014	836	880	542	264	30	555	287	38	0.907	0.206 (0.183)	No3
				(T > C)
3	2013	Breast cancer	DROSHA	rs2291109	899	957	563	296	40	625	298	34	0.835	0.191 (0.061)	Yes
				(A > T)
		Breast cancer	DGCR8	rs417309	901	960	830	68	3	910	49	1	0.687	0.027 (0.043)	Yes
				(G > A)
4	2013	Bladder cancer	DROSHA	rs2291109	685	730	421	228	36	419	280	31	0.062	0.234 (0.061)	Yes
				(A > T)
		Bladder cancer	DROSHA	rs10719	684	727	352	278	54	413	275	39	0.437	0.243 (0.483)	Yes
				(T > C)
		Bladder cancer	DROSHA	rs642321	685	730	197	326	162	176	371	183	0.655	0.505 (0.322)	Yes
				(C > T)
5	2013	Renal cell carcinoma	DROSHA	rs10719	252	246	161	75	16	155	76	15	0.177	0.215 (0.483)	Yes
				(T > C)
		Renal cell carcinoma	DROSHA	rs6877842	275	278	200	65	10	204	65	9	0.185	0.149 (0.138)	Yes
				(G > C)
		Renal cell carcinoma	DGCR8	rs3757	276	278	163	102	11	162	102	14	0.688	0.234 (0.182)	Yes
				(G > A)
		Renal cell carcinoma	DGCR8	rs417309	277	278	243	30	4	243	34	1	0.87	0.065 (0.043)	Yes
				(G > A)
		Renal cell carcinoma	DGCR8	rs1640299	277	278	61	151	65	75	136	67	0.729	0.486 (0.381)	Yes
				(T > G)
6	2015	Colorectal cancer	DROSHA	rs10719	408	400	224	154	30	211	168	21	0.09	0.263 (0.483)	Yes
				(T > C)
7	2015	Laryngeal cancer	DROSHA	rs6877842	128	170	73	49	6	76	79	15	0.384	0.321 (0.138)	Yes
				(G > C)
		Laryngeal cancer	DGCR8	rs417309	112	170	67	32	13	116	46	8	0.227	0.182 (0.043)	Yes
				(G > A)
		Laryngeal cancer	DGCR8	rs1640299	113	170	60	47	6	61	93	16	0.021	0.368 (0.381)	No2
				(T > G)
		Laryngeal cancer	DGCR8	rs3757	122	170	29	89	4	36	119	15	<0.001	0.438 (0.182)	No2
				(G > A)
8	2016	Laryngeal cancer	DROSHA	rs6877842	100	100	60	35	5	44	47	9	0.476	0.325 (0.138)	Yes
				(G > C)
		Laryngeal cancer	DGCR8	rs417309	100	100	60	28	12	69	27	4	0.516	0.175 (0.043)	Yes
				(G > A)
		Laryngeal cancer	DGCR8	rs1640299	100	100	52	42	6	36	55	9	0.062	0.365 (0.381)	Yes
				(T > G)
9	2016	Hepatocellular carcinoma	DROSHA	rs10719	147	209	81	53	13	110	88	11	0.215	0.263 (0.483)	Yes
				(T > C)
		Hepatocellular carcinoma	DROSHA	rs6877842	147	209	138	9	0	200	9	0	0.75	0.022 (0.138)	Yes
				(G > C)
10	2017	Gastirc cancer	DROSHA	rs10719	628	502	314	257	57	248	205	49	0.487	0.302 (0.483)	Yes
				(T > C)

The results were in bold if P<0.05. Abbreviations: MAF, minor allele frequency; P_HWE, the P-value for HWE in control groups.

¹, The ancestral alleles were referenced in the NCBI database.

², Excluded due to the SNP not being in accordance with HWE.

³, Excluded due to the limited number for this locus;

⁴, The global MAFs were referenced in the NCBI database.