Table 3. Meta-analysis of the association between DROSHA and DGCR8 polymorphisms and cancer risk.
| Heterozygote compared with homozygote wild | Homozygote variant compared with homozygote wild | Dominant model | Recessive model | Allelic model | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs | n | P (Pcorr) | OR (95% CI) | I2 (%) | P (Pcorr) | OR (95% CI) | I2 (%) | P (Pcorr) | OR (95% CI) | I2 (%) | P (Pcorr) | OR (95% CI) | I2 (%) | P (Pcorr) | OR (95% CI) | I2 (%) |
| DROSHA rs10719 (T > C) | 7 | 0.934 | 1.004 (0.904–1.117) | 0.2 | 0.055 | 1.214 (0.996–1.480) | 0.0 | 0.502 | 1.035 (0.936–1.145) | 10.5 | 0.053 | 1.210 (0.998–1.467) | 0.0 | 0.179 | 1.056 (0.975–1.145) | 0 |
| Ethnicity | ||||||||||||||||
| Asian | 6 | 0.874 | 1.009 (0.904–1.126) | 15.6 | 0.048 (0.336) | 1.230 (1.001–1.511) | 0.0 | 0.449 | 1.041 (0.938–1.157) | 10.5 | 0.04 (0.336) | 1.223 (1.002–1.494) | 0.0 | 0.154 | 1.062 (0.978–1.154) | 0 |
| Caucasian | 1 | 0.796 | 0.950 (0.645–1.400) | NA | 0.944 | 1.027 (0.491–2.148) | NA | 0.838 | 0.963 (0.668–1.387) | NA | 0.907 | 1.044 (0.504–2.161) | NA | 0.904 | 0.981 (0.725–1.329) | NA |
| Source of controls | ||||||||||||||||
| HB | 5 | 0.905 | 0.992 (0.869–1.132) | 30.1 | 0.071 | 1.257 (0.981–1.610) | 0 | 0.643 | 1.030 (0.908–1.169) | 27.2 | 0.061 | 1.259 (0.989–1.602) | 0 | 0.25 | 1.060 (0.0960–1.172) | 16.7 |
| PB | 2 | 0.767 | 1.027 (0.861–1.225) | 0 | 0.396 | 1.142 (0.822–1.588) | 0.0 | 0.616 | 1.044 (0.883–1.234) | 0 | 0.463 | 1.128 (0.818–1.555) | 0.0 | 0.398 | 1.049 (0.918-1.199) | 0 |
| DROSHA rs6877842 (G > C) | 5 | 0.174 | 0.841 (0.655–1.079) | 39.3 | 0.101 | 0.627 (0.358–1.096) | 0.0 | 0.3581 | 0.839 (0.577–1.220) | 50.7 | 0.218 | 0.706 (0.406–1.228) | 0.0 | 0.073 | 0.832 (0.680–1.017) | 48.2 |
| Ethnicity | ||||||||||||||||
| Asian | 2 | 0.292 | 1.438 (0.732–2.824) | 0 | 0.98 | 1.037 (0.064–16.860) | NA | 0.303 | 1.414 (0.731–2.735) | 0.0 | 1 | 1.000 (0.062–16.230) | NA | 0.326 | 1.372 (0.731–2.576) | 0 |
| Caucasian | 3 | 0.059 | 0.772 (0.590–1.010) | 47.1 | 0.094 | 0.613 (0.346–1.087) | 27.5 | 0.1251 | 0.716 (0.467–1.097) | 61.1 | 0.21 | 0.697 (0.396–1.225) | 0.0 | 0.1231 | 0.762 (0.540–1.076) | 60.1 |
| Source of controls | ||||||||||||||||
| HB | 3 | 0.395 | 0.845 (0.574–1.245) | 44.3 | 0.103 | 0.460 (0.181–1.169) | 0 | 0.881 | 0.953 (0.506–1.793) | 52.5 | 0.194 | 0.545 (0.218–1.361) | 0 | 0.155 | 0.796 (0.581–1.090) | 48.0 |
| PB | 1 | 0.922 | 1.020 (0.687–1.514) | NA | 0.79 | 1.133 (0.451–2.848) | NA | 0.862 | 1.034 (0.710–1.505) | NA | 0.797 | 1.128 (0.451–2.820) | NA | 0.807 | 1.042 (0.750–1.447) | NA |
| NM | 1 | 0.043 | 0.546 (0.304–0.981) | NA | 0.129 | 0.407 (0.128–1.300) | NA | 0.024 | 0.524 (0.299–0.919) | NA | 0.274 | 0.532 (0.172–1.648) | NA | 0.026 | 0.603 (0.387–0.941) | NA |
| Cancer type | ||||||||||||||||
| Laryngeal cancer | 2 | 0.008 (0.56) | 0.604 (0.417–0.875) | 0 | 0.022 (0.154) | 0.413 (0.193–0.881) | 0.0 | 0.002 (0.014) | 0.573 (0.401–0.819) | 0.0 | 0.081 | 0.518 (0.247–1.084) | 0.0 | 0.002 (0.014) | 0.638 (0.481–0.847) | 0.0 |
| Lung cancer | 1 | 0.469 | 1.426 (0.546–3.726) | NA | 0.98 | 1.037 (0.064–16.860) | NA | 0.488 | 1.383 (0.553–3.458) | NA | 1 | 1.000 (0.062–16.230) | NA | 0.52 | 1.323 (0.565–3.096) | NA |
| Hepatocellular carcinoma | 1 | 0.443 | 1.449 (0.561–3.744) | NA | NA | NA | NA | 0.443 | 1.449 (0.561–3.744) | NA | NA | NA | NA | 0.45 | 1.435 (0.563–3.660) | NA |
| Renal cell carcinoma | 1 | 0.922 | 1.020 (0.687–1.514) | NA | 0.79 | 1.133 (0.451–2.848) | NA | 0.862 | 1.034 (0.710–1.505) | NA | 0.797 | 1.128 (0.451–2.820) | NA | 0.807 | 1.042 (0.750–1.447) | NA |
| DROSHA rs642321 (C > T) | 2 | 0.576 | 0.918 (0.682–1.237) | 0.0 | 0.6721 | 0.934 (0.683–1.279) | 60.5 | 0.6031 | 0.923 (0.681–1.250) | 72.2 | 0.911 | 0.991 (0.843–1.165) | 0 | 0.6651 | 0.965 (0.821–1.134) | 62.3 |
| DROSHA rs2291109 (A > T) | 3 | 0.3891 | 0.922 (0.765–1.110) | 58.8 | 0.92 | 1.014 (0.771–1.333) | 44.7 | 0.4691 | 0.932 (0.770–1.128) | 63.8 | 0.746 | 1.046 (0.798–1.371) | 37.4 | 0.6061 | 0.958 (0.815–1.126) | 64.6 |
| Cancer type | ||||||||||||||||
| Breast cancer | 2 | 0.8511 | 0.977 (0.770–1.240) | 64.9 | 0.8991 | 0.962 (0.530–1.747) | 69.2 | 0.8591 | 0.975 (0.738–1.289) | 76.4 | 0.9091 | 0.971 (0.580–1.624) | 59.6 | 0.8711 | 0.978 (0.752–1.272) | 81 |
| Bladder cancer | 1 | 0.062 | 0.810 (0.650–1.011) | NA | 0.57 | 1.156 (0.702–1.903) | NA | 0.12 | 0.845 (0.683–1.045) | NA | 0.373 | 1.251 (0.765–2.046) | NA | 0.332 | 0.917 (0.768–1.093) | NA |
| Source of controls | ||||||||||||||||
| PB | 2 | 0.8511 | 0.977 (0.770–1.240) | 64.9 | 0.8991 | 0.962 (0.530–1.747) | 69.2 | 0.8591 | 0.975 (0.738–1.289) | 76.4 | 0.9091 | 0.971 (0.580–1.624) | 59.6 | 0.8711 | 0.978 (0.752–1.272) | 81 |
| HB | 1 | 0.062 | 0.810 (0.650–1.011) | NA | 0.57 | 1.156 (0.702–1.903) | NA | 0.12 | 0.845 (0.683–1.045) | NA | 0.373 | 1.251 (0.765–2.046) | NA | 0.332 | 0.917 (0.768–1.093) | NA |
| DGCR8 rs3757 (G > A) | 2 | 0.892 | 1.022 (0.750–1.391) | 0.0 | 0.741 | 0.894 (0.460–1.737) | 0 | 0.974 | 1.005 (0.748–1.350) | 0 | 0.715 | 0.885 (0.460–1.704) | 0 | 0.913 | 0.986 (0.772–1.260) | 0.0 |
| DGCR8 rs417309 (G > A) | 6 | 0.012 (0.084) | 1.282 (1.057–1.555) | 0.0 | 0.001 (0.007) | 3.169 (1.634–6.146) | 0 | 0.001 0.007) | 1.365 (1.131–1.647) | 0 | 0.001 (0.007) | 3.026 (1.574–5.817) | 0 | 6.90E-05 (4.83E-04) | 1.423 (1.196–1.693) | 0.0 |
| Ethnicity | ||||||||||||||||
| Asian | 3 | 0.004 (0.028) | 1.420 (1.115–1.809) | 0.0 | 0.303 | 3.289 (0.341–31.682) | NA | 0.003 0.021) | 1.435 (1.129–1.825) | 0 | 0.314 | 3.204 (0.333–30.856) | NA | 0.003 (0.021) | 1.429 (1.131–1.806) | 0.0 |
| Caucasian | 3 | 0.699 | 1.066 (0.772–1.472) | 0.0 | 0.001 (0.007) | 3.157 (1.579–6.310) | 0 | 0.133 | 1.260 (0.932–1.704) | 0 | 0.002 (0.014) | 3.009 (1.520–5.954) | 0 | 0.009 (0.063) | 1.415 (1.092–1.834) | 2.7 |
| Cancer type | ||||||||||||||||
| laryngeal cancer | 2 | 0.387 | 1.199 (0.795–1.810) | 0.0 | 0.003 (0.021) | 3.059 (1.474–6.351) | 0 | 0.05 | 1.460 (1.000–2.131) | 0 | 0.004 (0.028) | 2.895 (1.410–5.945) | 0 | 0.003 (0.021) | 1.604 (1.176–2.188) | 0.0 |
| Breast cancer | 2 | 0.003 (0.021) | 1.465 (1.141–1.881) | 0.0 | 0.303 | 3.289 (0.341–31.682) | NA | 0.002 (0.014) | 1.481 (1.155–1.898) | 0 | 0.314 | 3.204 (0.333–30.856) | NA | 0.002 (0.014) | 1.473 (1.157–1.876) | 0.0 |
| Lung cancer | 1 | 0.783 | 0.869 (0.321–2.355) | NA | NA | NA | NA | 0.783 | 0.869 (0.321–2.355) | NA | NA | NA | NA | 0.788 | 0.875 (0.330–2.316) | NA |
| Renal cell carcinoma | 1 | 0.638 | 0.882 (0.523–1.487) | NA | 0.217 | 4.000 (0.444–36.046) | NA | 0.91 | 0.971 (0.587–1.609) | NA | 0.212 | 4.059 (0.451–36.544) | NA | 0.797 | 1.064 (0.664–1.705) | NA |
| Source of controls | ||||||||||||||||
| PB | 3 | 0.012 (0.084) | 1.333 (1.065–1.669) | 33.7 | 0.107 | 3.652 (0.755–17.659) | 0 | 0.006 (0.042) | 1.364 (1.093–1.704) | 12.4 | 0.036 (0.252) | 2.659 (1.064–6.643) | NA | 0.059 | 1.434 (0.986–2.085) | 14.7 |
| HB | 2 | 0.648 | 1.117 (0.694–1.799) | 0.0 | 0.029 (0.203) | 2.813 (1.109–7.135) | NA | 0.243 | 1.302 (0.836–2.030) | 0 | 0.108 | 3.635 (0.752–17.564) | 0 | 0.003 (0.021) | 1.377 (1.111–1.707) | 0.0 |
| NM | 1 | 0.585 | 1.193 (0.634–2.243) | NA | 0.04 | 3.450 (1.057–11.265) | NA | 0.184 | 1.484 (0.828–2.658) | NA | 0.047 | 3.273 (1.018–10.523) | NA | 0.04 | 1.656 (1.022–2.684) | NA |
| DGCR8 rs1640299 (T > G) | 4 | 0.5081 | 0.895 (0.645–1.243) | 60.2 | 0.988 | 0.998 (0.751–1.325) | 0 | 0.494 | 0.898 (0.659–1.223) | 59.1 | 0.786 | 0.965 (0.745–1.249) | 0 | 0.48 | 0.959 (0.852–1.078) | 34.6 |
| Ethnicity | ||||||||||||||||
| Asian | 2 | 0.403 | 0.923 (0.766–1.113) | 0.0 | 0.91 | 0.979 (0.674–1.420) | 0 | 0.434 | 0.931 (0.778–1.114) | 0 | 0.952 | 1.011 (0.703–1.455) | 0 | 0.545 | 0.957 (0.829–1.104) | 0.0 |
| Caucasian | 2 | 0.7691 | 0.870 (0.344–2.202) | 85.3 | 0.7261 | 0.853 (0.350–2.076) | 57.3 | 0.7131 | 0.844 (0.342–2.085) | 85.6 | 0.656 | 0.920 (0.638–1.328) | 0 | 0.5761 | 0.864 (0.517–1.443) | 77.9 |
| Source of controls | ||||||||||||||||
| PB | 2 | 0.6431 | 1.086 (0.767–1.537) | 60.2 | 0.788 | 1.043 (0.770–1.412) | 0 | 0.6941 | 1.063 (0.785–1.439) | 53.5 | 0.831 | 0.971 (0.738–1.276) | 0 | 0.974 | 0.998 (0.879–1.133) | 0.0 |
| HB | 1 | 0.32 | 0.740 (0.408–1.339) | NA | 0.712 | 1.255 (0.375–4.197) | NA | 0.433 | 0.797 (0.452–1.405) | NA | 0.565 | 1.415 (0.433–4.623) | NA | 0.682 | 0.908 (0.574-–1.438) | NA |
| NM | 1 | 0.033 | 0.529 (0.295–0.949) | NA | 0.175 | 0.462 (0.151–1.410) | NA | 0.023 | 0.519 (0.295–0.915) | NA | 0.424 | 0.645 (0.221–1.886) | NA | 0.042 | 0.643 (0.421–0.984) | NA |
The results are in bold if P<0.05. Abbreviation: Pcorr, P-values after Bonferroni correction.
1, P was calculated by random model.