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525例肺癌患者肿瘤细胞中ALK蛋白表达情况及与临床病理特征的关系

Correlation between ALK protein expression and clinicopathological factors in 525 lung cancer patients with non-small cell lung cancer

Features	All	ALK protein expression (IHC by using D5F3)
	(n=525)	Positive	Negative	P
		(n=27)	(n=498)
Ca.: carcinoma; LCNEC: large cell neuroendocrine carcinoma; Ad.: adenocarcinoma; Diff.: differentiation. Statistical analyses were performed using Pearson Chi-Square test. *P < 0.05.
Age (years)				0.002*
≥50	476 (90.67%)	19 (70.37%)	457 (91.77%)
< 50	49 (9.33%)	8 (29.36%)	41 (8.23%)
Sex				0.002*
Male	284 (54.10%)	7 (25.93%)	277 (55.62%)
Female	241 (45.90%)	20 (74.07%)	221 (44.38%)
Histology
Adenocarcinoma	400 (76.20%)	24 (88.89%)	376 (75.50%)
Solid predominant	73 (13.90%)	10 (37.04%)	63 (12.65%)	0.002*
Acinar predominant	232 (44.19%)	7 (25.93%)	225 (45.18%)	0.037*
Papillary predominant	57 (10.86%)	6 (22.22%)	51 (10.24%)	0.061
Micropapillary pre	9 (1.71%)	1 (3.70%)	8 (1.61%)	0.381
Lepidic predominant	29 (5.52%)	0	29 (5.82%)	< 0.001*
Squamous cell carcinoma	94 (17.90%)	2 (7.41%)	92 (18.47%)	0.108
Adenosquamous carcinoma	13 (2.48%)	1 (3.70%)	12 (2.41%)	0.501
LCNEC	12 (2.29%)	0	12 (2.41%)
Mixed small cell/large cell	2 (0.38%)	0	2 (0.40%)
Carcinoid tumor	2 (0.38%)	0	2 (0.40%)
Sarcomatoid Ca.	1 (0.19%)	0	1 (0.20%)
Adenoid cystic Ca.	1 (0.19%)	0	1 (0.20%)
Other specific histologic features
Ad. with Signet cells > 10%	7 (1.33%)	1 (3.70%)	6 (1.20%)	0.310
Ad. with mucinous Ad. Diff.	19 (3.62%)	3 (11.11%)	16 (3.21%)	0.068