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. 2018 Jun 26;16(6):e2005086. doi: 10.1371/journal.pbio.2005086

Fig 2. Mosaic proliferation blockade in the left limb cartilage slightly reduces bone growth but not left–right limb symmetry.

Fig 2

(A) Absolute length of the indicated left bones of ePit-p21 (n = 4–7 depending on the bone) and ePit-Col-p21 (n = 11–15) E17.5 embryos. (B, C) Skeletal preparations (panel B) and quantification of the left/right ratio (panel C, mean ± SD) of the calcified region of the indicated bones at E17.5 (n = 4–7 ePit-p21 and n = 11–15 ePit-Col-p21 mice, depending on the bone) and P0 (n = 5–9, and 6–9). Dashed lines in panel B mark the ends of the mineralized region in control bones. In panel A and C, data were analysed by 2-way ANOVA with Genotype and Bone identity as variables. p-Values are shown below the graphs. For variables with significantly different measurements, Sidak’s post hoc test p-values are shown in the graph. For panel A and C, see S3 Data. E, embryonic day; P, postnatal day.