Table 3. Functional enrichment analysis using a gene set enrichment analysis (GSEA).
Gene Ontology name | Number of genes | P-value | FDR |
---|---|---|---|
Biological process_UP | |||
Sensory organ development | 23 | <0.001 | 0.123 |
Collagen fibril organization | 10 | <0.001 | 0.077 |
Response to growth factor | 20 | <0.001 | 0.201 |
Ear development | 11 | <0.001 | 0.164 |
Extracellular structure organization | 42 | <0.001 | 0.17 |
Heart development | 23 | <0.001 | 0.162 |
Biological process_DOWN | |||
Gamete generation | 13 | <0.001 | 0.216 |
Cellular components_UP | |||
Extracellular matrix | 61 | <0.001 | 0.069 |
Proteinaceous extracellular matrix | 52 | 0.014 | 0.211 |
Endoplasmic reticulum lumen | 19 | 0.013 | 0.192 |
Cell cortex | 10 | 0.016 | 0.237 |
Basement membrane | 17 | 0.045 | 0.209 |
Cell leading edge | 14 | <0.001 | 0.203 |
Cell substrate junction | 15 | 0.048 | 0.213 |
Collagen trimer | 14 | 0.018 | 0.197 |
Anchoring junction | 15 | 0.014 | 0.208 |
Endoplasmic reticulum | 55 | 0.042 | 0.211 |
Cellular components_DOWN | |||
None | |||
Molecular functions_UP | |||
Growth factor binding | 14 | 0.015 | 0.21 |
Tracellulra matrix structural constituent | 15 | 0.029 | 0.217 |
Prptein complex binding | 31 | <0.001 | 0.212 |
Cell adhesion molecule binding | 11 | 0.031 | 0.238 |
Transcription factor binding | 11 | 0.03 | 0.21 |
Identical protein binding | 34 | 0.041 | 0.204 |
Molecular functions_DOWN | |||
Cation transmembrane transporter activity | 13 | 0.045 | 0.183 |
Transporter activity | 29 | <0.001 | 0.225 |
Dominant functions (p < 0.05 and FDR-q < 0.25) are listed in the table.