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. 2018 Jun 26;13(6):e0199734. doi: 10.1371/journal.pone.0199734

Table 3. Functional enrichment analysis using a gene set enrichment analysis (GSEA).

Gene Ontology name Number of genes P-value FDR
Biological process_UP
 Sensory organ development 23 <0.001 0.123
 Collagen fibril organization 10 <0.001 0.077
 Response to growth factor 20 <0.001 0.201
 Ear development 11 <0.001 0.164
 Extracellular structure organization 42 <0.001 0.17
 Heart development 23 <0.001 0.162
Biological process_DOWN
 Gamete generation 13 <0.001 0.216
Cellular components_UP
 Extracellular matrix 61 <0.001 0.069
 Proteinaceous extracellular matrix 52 0.014 0.211
 Endoplasmic reticulum lumen 19 0.013 0.192
 Cell cortex 10 0.016 0.237
 Basement membrane 17 0.045 0.209
 Cell leading edge 14 <0.001 0.203
 Cell substrate junction 15 0.048 0.213
 Collagen trimer 14 0.018 0.197
 Anchoring junction 15 0.014 0.208
 Endoplasmic reticulum 55 0.042 0.211
Cellular components_DOWN
 None
Molecular functions_UP
Growth factor binding 14 0.015 0.21
Tracellulra matrix structural constituent 15 0.029 0.217
 Prptein complex binding 31 <0.001 0.212
Cell adhesion molecule binding 11 0.031 0.238
Transcription factor binding 11 0.03 0.21
 Identical protein binding 34 0.041 0.204
Molecular functions_DOWN
 Cation transmembrane transporter activity 13 0.045 0.183
 Transporter activity 29 <0.001 0.225

Dominant functions (p < 0.05 and FDR-q < 0.25) are listed in the table.