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. 2018 Jun 26;13(6):e0199734. doi: 10.1371/journal.pone.0199734

Table 4. The upregulated pathways in OA chondrocytes.

pathway P-value Ratio
(KEGG) 00052: Galactose metabolism 0.0019 0.11
(KEGG) 00480: Glutathione metabolism 0.0075 0.07
(KEGG) 03320: PPAR signaling pathway 0.026 0.04
(KEGG) 04010: MAPK signaling pathway 0.038 0.04
(KEGG) 04060: Cytokine-cytokine receptor interaction 0.00088 0.14
(KEGG) 04080: Neuroactive ligand-receptor interaction 0.00084 0.03
(KEGG) 04110: Cell cycle 0.00025 0.21
(KEGG) 04115: p53 signaling pathway 0.0013 0.13
(KEGG) 04144: Endocytosis 0.0087 0.03
(KEGG) 04145: Phagosome 8.52E-05 0.30
(KEGG) 04310: Wnt signaling pathway 0.0029 0.06
(KEGG) 04340: Hedgehog signaling pathway 0.0030 0.09
(KEGG) 04350: TGF-beta signaling pathway 0.00088 0.14
(KEGG) 04360: Axon guidance 0.0064 0.04
(KEGG) 04510: Focal adhesion 9.66E-13 0.47
(KEGG) 04512: ECM-receptor interaction 9.66E-13 0.47
(KEGG) 04514: Cell adhesion molecules (CAMs) 8.52E-05 0.30
(KEGG) 04540: Gap junction 0.00046 0.18
(KEGG) 04612: Antigen processing and presentation 8.52E-05 0.30
(KEGG) 04640: Hematopoietic cell lineage 0.0070 0.05
(KEGG) 04670: Leukocyte transendothelial migration 0.020 0.04
(KEGG) 04672: Intestinal immune network for IgA production 8.52E-05 0.30
(KEGG) 04810: Regulation of actin cytoskeleton 0.043 0.02
(KEGG) 04940: Type I diabetes mellitus 8.52E-05 0.30
(KEGG) 04974: Protein digestion and absorption 9.66E-13 0.47
(KEGG) 04976: Bile secretion 0.027 0.04
(KEGG) 05130: Pathogenic Escherichia coli infection 0.00046 0.18
(KEGG) 05140: Leishmaniasis 8.52E-05 0.30
(KEGG) 05145: Toxoplasmosis 8.52E-05 0.30
(KEGG) 05146: Amoebiasis 7.29E-08 0.38
(KEGG) 05150: Staphylococcus aureus infection 8.52E-05 0.30
(KEGG) 05152: Tuberculosis 8.52E-05 0.30
(KEGG) 05200: Pathways in cancer 0.00025 0.21
(KEGG) 05210: Colorectal cancer 0.0046 0.08
(KEGG) 05212: Pancreatic cancer 0.00025 0.21
(KEGG) 05215: Prostate cancer 0.046 0.03
(KEGG) 05217: Basal cell carcinoma 0.0030 0.09
(KEGG) 05218: Melanoma 0.0038 0.06
(KEGG) 05219: Bladder cancer 0.00057 0.10
(KEGG) 05220: Chronic myeloid leukemia 0.00025 0.21
(KEGG) 05222: Small cell lung cancer 0.0066 0.07
(KEGG) 05310: Asthma 8.52E-05 0.30
(KEGG) 05320: Autoimmune thyroid disease 8.52E-05 0.30
(KEGG) 05322: Systemic lupus erythematosus 8.52E-05 0.30
(KEGG) 05323: Rheumatoid arthritis 8.52E-05 0.30
(KEGG) 05330: Allograft rejection 8.52E-05 0.30
(KEGG) 05332: Graft-versus-host disease 8.52E-05 0.30
(KEGG) 05410: Hypertrophic cardiomyopathy (HCM) 0.0045 0.05
(KEGG) 05412: Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.029 0.04
(KEGG) 05414: Dilated cardiomyopathy 0.0045 0.05
(KEGG) 05416: Viral myocarditis 8.52E-05 0.30

The ratio is calculated by dividing the number of overexpressed genes in OA chondrocytes by the total number of genes contained in the pathway. Pathways overlapped in the comparative analysis between our secondary OA data and primary one [13] are shown in bold letters.