CCA reveals inter-correlations between global graphical measures and cognitive scores [(A), correlation = 0.98, p = 0.01]. The error bars indicate 95% confidence interval in leave-one-out cross validation. If the error bars do not cross zero, the variables are recognized as significant. Among global measures (B), assortativity, modularity and transitivity show significant loadings. In the combination of cognitive scores (C), MoCA, BJLO, HVLY delay recall, standardized HVLT total, standardized HVLT retention, LNS, and SF scores contribute significant loadings. assor, assortativity; chapath, characteristic path length; rich club, rich club coefficient; trans, transitivity; MOCA, Montreal Cognitive Assessment; BJLOTOT, Bento Line Orientation Total Score; HVLTTOT, Hopkins Verbal Learning Test-Revised Total Score; HVLTDELAY, HVLT Delayed Recall Score; DVT-HVLTTOTAL, standardized HVLT Total Score; DVT-HVLTDELAY, standardized HVLT Delayed Recall Score; DVT-HVLTRETENTION, standardized HVLT Recognition Trial Score; LNS, raw Letter-Number Sequencing Test Score; SFCOM, Sematic Fluency Test—combination; SDMTTOT, Symbol Digit Modalities Test total scores.